JNJ 0966
Tocris Bioscience, part of Bio-Techne | Catalog # 6439
Pro-MMP9 activation inhibitor
Key Product Details
Description
Pro-MMP9 activation inhibitor
Product Description
JNJ 0966 is a pro-MMP9 activation inhibitor (IC50 = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.Product Specifications
Molecular Weight
360.45
Formula
C16H16N4O2S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide
CAS Number
315705-75-0
PubChem ID
1117189
InChI Key
ZADCDCMLLGDCRM-UHFFFAOYSA-N
SMILES
COC1=C(C=CC=C1)NC2=NC(C3=C(N=C(S3)NC(C)=O)C)=CS2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.02 | 50 |
Preparing Stock Solutions
for JNJ 0966
The following data is based on the product molecular weight 360.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.55 mL | 27.74 mL | 55.49 mL |
| 2.5 mM | 1.11 mL | 5.55 mL | 11.10 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.55 mL |
| 25 mM | 0.11 mL | 0.55 mL | 1.11 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Scannevin Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J.Biol.Chem. 2017 PMID: 28860188
Product Specific Notices for JNJ 0966
For research use only
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