JMV 449
Tocris Bioscience, part of Bio-Techne | Catalog # 1998
Potent neurotensin receptor agonist
Key Product Details
Description
Potent neurotensin receptor agonist
Product Description
JMV 449 is a potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.Product Specifications
Molecular Weight
746.96
Formula
C38H66N8O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
139026-66-7
PubChem ID
164415
InChI Key
TZCYVPLNMOJUIL-GULBXNHPSA-N
SMILES
[H]N[C@@H](CCCCN)CN[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 0.8mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Dubuc JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 1992 PMID: 1425958
- Torup Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 2003 PMID: 14623134
- Lugrin Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 1991 PMID: 1812009
Product Specific Notices for JMV 449
For research use only
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