JMS 17-2 hydrochloride

Name: JMS 17-2 hydrochloride
Brand: Tocris Bioscience
SKU: 6378

Tocris Bioscience, part of Bio-Techne | Catalog # 6378

Citations (1)

COA / SDS

CX3CR1 antagonist

Key Product Details

Description:	CX3CR1 antagonist
Chemical Name:	5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	456.41

View Full Technical Details for JMS 17-2 hydrochloride

Technical Data
Citations

Biological Activity for JMS 17-2 hydrochloride

JMS 17-2 hydrochloride is a chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.

Licensing Information

Sold under license from Drexel University.

Compound Libraries for JMS 17-2 hydrochloride

JMS 17-2 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for JMS 17-2 hydrochloride

M. Wt	456.41
Formula	C₂₅H₂₆ClN₃O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2341841-07-2
Smiles	ClC1=CC=C(C2CCN(CC2)CCCN3C(C4=CC=CN4C5=CC=CC=C35)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JMS 17-2 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.64	100
	ethanol	22.82	50

Preparing Stock Solutions for JMS 17-2 hydrochloride

The following data is based on the product molecular weight 456.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.96 mL	21.91 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.10 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for JMS 17-2 hydrochloride

References are publications that support the biological activity of the product.

Shen Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells. Mol. Cancer Res. 2016 PMID: 27001765