JH-II-127
Tocris Bioscience, part of Bio-Techne | Catalog # 6289
Potent and selective LRRK2 inhibitor
Product Description
JH-II-127 is a potent and selective LRRK2 inhibitor (IC50 values are 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively). Selective for LRRK2 over a panel of 138 kinases. Brain penetrant and orally bioavailable.Licensing Information
Sold under license from Dana-Farber Cancer Institute.Product Specifications
Molecular Weight
416.87
Formula
C19H21ClN6O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone
CAS Number
1700693-08-8
PubChem ID
112499966
InChI Key
HUEKBQXFNHWTQQ-UHFFFAOYSA-N
SMILES
O=C(N1CCOCC1)C2=CC(OC)=C(NC3=NC(NC)=C(C(Cl)=CN4)C4=N3)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.69 | 100 |
Preparing Stock Solutions
for JH-II-127
The following data is based on the product molecular weight 416.87
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.40 mL | 11.99 mL | 23.99 mL |
| 5 mM | 0.48 mL | 2.40 mL | 4.80 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hatcher Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor. ACS Med.Chem.Lett. 2015 PMID: 26005538
Product Specific Notices for JH-II-127
For research use only
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