Jedi2

Name: Jedi2
Brand: Tocris Bioscience
SKU: 6614

Tocris Bioscience, part of Bio-Techne | Catalog # 6614

Citations (13)

COA / SDS

Piezo1 channel activator

Key Product Details

Description:	Piezo1 channel activator
Chemical Name:	2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	208.23

View Full Technical Details for Jedi2

Technical Data
Citations

Biological Activity for Jedi2

Jedi2 is a piezo1 channel activator. Promotes Ca²⁺ influx into HEK293 cells expressing Piezo1 channels. Elicits responses in mouse Piezo1-transfected, but not Piezo2-transfected cells.

Compound Libraries for Jedi2

Jedi2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Jedi2

M. Wt	208.23
Formula	C₁₀H₈O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	651005-90-2
PubChem ID	2796026
InChi Key	YXDCRSXNEOKXDE-UHFFFAOYSA-N
Smiles	CC1=C(C(O)=O)C=C(C2=CC=CS2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Jedi2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.82	100
	ethanol	20.82	100

Preparing Stock Solutions for Jedi2

The following data is based on the product molecular weight 208.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.80 mL	24.01 mL	48.02 mL
5 mM	0.96 mL	4.80 mL	9.60 mL
10 mM	0.48 mL	2.40 mL	4.80 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

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Reconstitution Calculator

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References for Jedi2

References are publications that support the biological activity of the product.

Wang A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat.Commun. 2018 PMID: 29610524