J 104129 fumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 2507
Potent and selective M3 antagonist
Product Description
J 104129 fumarate is a potent M3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490 nM for human M3, M1 and M2 receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea M3 and rat right atria M2 receptors respectively).Product Specifications
Molecular Weight
500.63
Formula
C24H36N2O2.C4H4O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate
CAS Number
257603-40-0
PubChem ID
56972189
InChI Key
HUCQUCITPHOUAC-DSSYAJFBSA-N
SMILES
[H]OC(=O)\C=C\C(=O)O[H].C\C(C)=C\CCN1CCC(CC1)NC(=O)[C@@](O)(C1CCCC1)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.06 | 100 | |
| Ethanol | 25.03 | 50 |
Preparing Stock Solutions
for J 104129 fumarate
The following data is based on the product molecular weight 500.63
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.00 mL | 9.99 mL | 19.97 mL |
| 5 mM | 0.40 mL | 2.00 mL | 3.99 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mitsuya Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg.Med.Chem. 2000 PMID: 10819171
- Mitsuya Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129. Bioorrg.Med.Chem.Lett.
- Mitsuya J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg.Med.Chem. 1999 PMID: 10632066
Product Specific Notices for J 104129 fumarate
For research use only
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