Ivabradine hydrochloride

Name: Ivabradine hydrochloride
Brand: Tocris Bioscience
SKU: 6542
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6542

(1)

Citations (12)

COA / SDS

HCN channel blocker; inhibits If pacemaker current

Key Product Details

Description:	HCN channel blocker; inhibits I_f pacemaker current
Chemical Name:	3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	505.05

View Full Technical Details for Ivabradine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Ivabradine hydrochloride

Ivabradine hydrochloride is a HCN channel blocker (IC₅₀ is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits I_f pacemaker current in sinoatrial node cells.

Compound Libraries for Ivabradine hydrochloride

Ivabradine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ivabradine hydrochloride

M. Wt	505.05
Formula	C₂₇H₃₆N₂O₅.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	148849-67-6
PubChem ID	3045381
InChi Key	HLUKNZUABFFNQS-ZMBIFBSDSA-N
Smiles	COC1=C(C=C2[C@H](CC2=C1)CN(CCCN3CCC4=CC(OC)=C(C=C4CC3=O)OC)C)OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ivabradine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	50.51	100
	DMSO	50.51	100

Preparing Stock Solutions for Ivabradine hydrochloride

The following data is based on the product molecular weight 505.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.90 mL	19.80 mL
5 mM	0.40 mL	1.98 mL	3.96 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Ivabradine hydrochloride

References are publications that support the biological activity of the product.

Novella Romanelli HCN channel modulators: the need for selectivity. Curr.Top.Med.Chem. 2016 PMID: 26975509
Thollon Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br.J.Pharmacol. 1994 PMID: 8032660