Istradefylline
Tocris Bioscience, part of Bio-Techne | Catalog # 5147
Potent and selective A2A antagonist
Key Product Details
Description
Potent and selective A2A antagonist
Alternative Names
KW-6002
Product Description
Istradefylline is a potent and selective adenosine A2A receptor antagonist (Ki values are 2.2 and 150 nM for A2A and A1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.Product Specifications
Molecular Weight
384.43
Formula
C20H24N4O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
CAS Number
155270-99-8
PubChem ID
5311037
InChI Key
IQVRBWUUXZMOPW-PKNBQFBNSA-N
SMILES
O=C1N(CC)C(C(N(C)C(/C=C/C3=CC(OC)=C(OC)C=C3)=N2)=C2N1CC)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.69 | 20 |
Preparing Stock Solutions
for Istradefylline
The following data is based on the product molecular weight 384.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.01 mL | 65.03 mL | 130.06 mL |
| 1 mM | 2.60 mL | 13.01 mL | 26.01 mL |
| 2 mM | 1.30 mL | 6.50 mL | 13.01 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kanda Adenosine A2A receptors modify motor function in MPTP-treated common marmosets. Neuroreport 1998 PMID: 9760134
- Shiozaki Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by rese. or MPTP. Psychopharmacology 1999 PMID: 10591873
- Shimada Adenosine A2A antagonists with potent anti-cataleptic activity. Bioorg.Med.Chem.Lett.
Product Specific Notices for Istradefylline
For research use only
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