Istradefylline

Name: Istradefylline
Brand: Tocris Bioscience
SKU: 5147
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5147

(1)

Citations (28)

COA / SDS

Potent and selective A2A antagonist

Key Product Details

Description:	Potent and selective A_2A antagonist
Alternative Names:	KW-6002
Chemical Name:	8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
Purity:	≥98% (HPLC)
Molecular Weight:	384.43

View Full Technical Details for Istradefylline

Technical Data
Citations / Reviews (1)

Biological Activity for Istradefylline

Istradefylline is a potent and selective adenosine A_2A receptor antagonist (K_i values are 2.2 and 150 nM for A_2A and A₁ receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.

Technical Data for Istradefylline

M. Wt	384.43
Formula	C₂₀H₂₄N₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	155270-99-8
PubChem ID	5311037
InChi Key	IQVRBWUUXZMOPW-PKNBQFBNSA-N
Smiles	O=C1N(CC)C(C(N(C)C(/C=C/C3=CC(OC)=C(OC)C=C3)=N2)=C2N1CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Istradefylline

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.69	20

Preparing Stock Solutions for Istradefylline

The following data is based on the product molecular weight 384.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.01 mL	65.03 mL	130.06 mL
1 mM	2.60 mL	13.01 mL	26.01 mL
2 mM	1.30 mL	6.50 mL	13.01 mL
10 mM	0.26 mL	1.30 mL	2.60 mL

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References for Istradefylline

References are publications that support the biological activity of the product.

Kanda Adenosine A_2A receptors modify motor function in MPTP-treated common marmosets. Neuroreport 1998 PMID: 9760134
Shiozaki Actions of adenosine A_2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by rese. or MPTP. Psychopharmacology 1999 PMID: 10591873
Shimada Adenosine A_2A antagonists with potent anti-cataleptic activity. Bioorg.Med.Chem.Lett.