Isoguvacine hydrochloride

Name: Isoguvacine hydrochloride
Brand: Tocris Bioscience
SKU: 0235

Tocris Bioscience, part of Bio-Techne | Catalog # 0235

Citations (12)

COA / SDS

Selective GABAA agonist

Key Product Details

Description:	Selective GABA_A agonist
Chemical Name:	1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	163.6

View Full Technical Details for Isoguvacine hydrochloride

Technical Data
Citations

Biological Activity for Isoguvacine hydrochloride

Isoguvacine hydrochloride is a specific GABA_A receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.

Technical Data for Isoguvacine hydrochloride

M. Wt	163.6
Formula	C₆H₉NO₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	68547-97-7
PubChem ID	155107
InChi Key	SUWREQRNTXCCBL-UHFFFAOYSA-N
Smiles	Cl.OC(=O)C=1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Isoguvacine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for Isoguvacine hydrochloride

The following data is based on the product molecular weight 163.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.11 mL	30.56 mL	61.12 mL
5 mM	1.22 mL	6.11 mL	12.22 mL
10 mM	0.61 mL	3.06 mL	6.11 mL
50 mM	0.12 mL	0.61 mL	1.22 mL

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Reconstitution Calculator

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References for Isoguvacine hydrochloride

References are publications that support the biological activity of the product.

Krogsgaard-Larsen Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 1979 PMID: 448364
Wahab Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 2009 PMID: 19535226
Krogsgaard-Larsen Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 1978 PMID: 670980