Irbesartan
Tocris Bioscience, part of Bio-Techne | Catalog # 5798
Potent AT1 antagonist
Key Product Details
Description
Potent AT1 antagonist
Product Description
Irbesartan is a potent angiotensin II type 1 receptor (AT1) antagonist (IC50 = 1.3 nM). Displays antihypertensive activity. Orally bioavailable.Product Specifications
Molecular Weight
428.53
Formula
C25H28N6O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
CAS Number
138402-11-6
PubChem ID
3749
InChI Key
YOSHYTLCDANDAN-UHFFFAOYSA-N
SMILES
O=C(C1(CCCC1)N=C2CCCC)N2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.85 | 100 | |
| Ethanol | 4.29 | 10 |
Preparing Stock Solutions
for Irbesartan
The following data is based on the product molecular weight 428.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Burnier Angiotensin II type 1 receptor blockers. Circulation 2001 PMID: 11171802
Product Specific Notices for Irbesartan
For research use only
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