IQ 1
Tocris Bioscience, part of Bio-Techne | Catalog # 4713
Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation
Discontinued Product
4713 has been discontinued.
View all Compounds for Induced Pluripotent Stem Cells products.
Key Product Details
Description
Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation
Product Description
IQ 1 is a maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.Product Specifications
Molecular Weight
362.42
Formula
C21H22N4O2
Storage
Store at -20°C
Purity
≥99% (HPLC)
Chemical Name
2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide
CAS Number
331001-62-8
PubChem ID
56801
InChI Key
XTZNCVSCVHTPAI-UHFFFAOYSA-N
SMILES
CC(C(C=C3)=CC=C3/N=N/C(C(N)=O)=C2\C1=CC=CC=C1CC(C)(C)N2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.24 | 100 | |
| Ethanol | 7.25 | 20 |
Preparing Stock Solutions
for IQ 1
The following data is based on the product molecular weight 362.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.76 mL | 13.80 mL | 27.59 mL |
| 5 mM | 0.55 mL | 2.76 mL | 5.52 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Miyabayashi Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc.Natl.Acad.Sci.U S A 2007 PMID: 17372190
Product Specific Notices for IQ 1
For research use only
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