IOX 1
Tocris Bioscience, part of Bio-Techne | Catalog # 4464
Histone demethylase inhibitor; cell permeable
Key Product Details
Description
Histone demethylase inhibitor; cell permeable
Alternative Names
5-carboxy-8HQ
Product Description
IOX 1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4+ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 1 summary on the SGC website.Product Specifications
Molecular Weight
189.17
Formula
C10H7NO3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
8-Hydroxy-5-quinolinecarboxylic acid
CAS Number
5852-78-8
PubChem ID
459617
InChI Key
JGRPKOGHYBAVMW-UHFFFAOYSA-N
SMILES
OC2=CC=C(C(O)=O)C1=CC=CN=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.92 | 100 | |
| 1eq. NaOH | 18.92 | 100 |
Preparing Stock Solutions
for IOX 1
The following data is based on the product molecular weight 189.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.29 mL | 26.43 mL | 52.86 mL |
| 5 mM | 1.06 mL | 5.29 mL | 10.57 mL |
| 10 mM | 0.53 mL | 2.64 mL | 5.29 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.06 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hu Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. EBioMedicine 2022 PMID: 36335665
- King Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One. 2010 PMID: 21124847
Product Specific Notices for IOX 1
For research use only
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