IOX 1

Name: IOX 1
Brand: Tocris Bioscience
SKU: 4464

Tocris Bioscience, part of Bio-Techne | Catalog # 4464

Citations (11)

COA / SDS

Histone demethylase inhibitor; cell permeable

Key Product Details

Description:	Histone demethylase inhibitor; cell permeable
Alternative Names:	5-carboxy-8HQ
Chemical Name:	8-Hydroxy-5-quinolinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	189.17

View Full Technical Details for IOX 1

Technical Data
Citations

Biological Activity for IOX 1

IOX 1 is a histone demethylase JMJD inhibitor (IC₅₀ values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4⁺ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 1 summary on the SGC website.

Compound Libraries for IOX 1

IOX 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for IOX 1

M. Wt	189.17
Formula	C₁₀H₇NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	5852-78-8
PubChem ID	459617
InChi Key	JGRPKOGHYBAVMW-UHFFFAOYSA-N
Smiles	OC2=CC=C(C(O)=O)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IOX 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.92	100
	1eq. NaOH	18.92	100

Preparing Stock Solutions for IOX 1

The following data is based on the product molecular weight 189.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.29 mL	26.43 mL	52.86 mL
5 mM	1.06 mL	5.29 mL	10.57 mL
10 mM	0.53 mL	2.64 mL	5.29 mL
50 mM	0.11 mL	0.53 mL	1.06 mL

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References for IOX 1

References are publications that support the biological activity of the product.

Hu Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. EBioMedicine 2022 PMID: 36335665
King Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One. 2010 PMID: 21124847