Iodophenpropit dihydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 0779
Potent, selective H3 antagonist
Discontinued Product
0779 has been discontinued.
View all Histamine H3 Receptor Antagonists products.
Key Product Details
Description
Potent, selective H3 antagonist
Product Description
Iodophenpropit dihydrobromide is a selective H3 antagonist with high affinity (KD = 0.3 nM).Licensing Information
Sold with the permission of SCI, AmsterdamProduct Specifications
Molecular Weight
576.13
Formula
C15H19IN4S.2HBr
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
CAS Number
145196-87-8
PubChem ID
24978528
InChI Key
BOSOGNBLIWPCMS-UHFFFAOYSA-N
SMILES
Br.Br.IC1=CC=C(CCNC(=N)SCCCC2=CNC=N2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.4 | 25 |
Preparing Stock Solutions
for Iodophenpropit dihydrobromide
The following data is based on the product molecular weight 576.13
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 6.94 mL | 34.71 mL | 69.43 mL |
| 1.25 mM | 1.39 mL | 6.94 mL | 13.89 mL |
| 2.5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 12.5 mM | 0.14 mL | 0.69 mL | 1.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shahid Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J.
- Jansen Characterisation of the binding of the first selective radiolabelled histamine H3 receptor antagonist, [125I]-iodophenpropit, to rat brain. Br.J.Pharmacol. 1994 PMID: 7834183
- Menge Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites. J.Labelled Comp.Radiopharm. XXXI
- Jansen The first radiolabelled histamine H3 receptor antagonist, [125I]iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur.J.Pharmacol. 1992 PMID: 1330590
Product Specific Notices for Iodophenpropit dihydrobromide
For research use only
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