INT 131
Tocris Bioscience, part of Bio-Techne | Catalog # 7423
PPARγ partial agonist
Product Description
INT 131 is a potent and selective PPARγ partial agonist (EC50 = 4 nM; Ki = 3.7 nM). It has a 20-fold higher affinity for PPARγ compared with that of Rosiglitazone (Cat. No. 5325). INT 131 improves glucose tolerance in a rodent model of diabetes without inducing hemodynamic and cardiovascular effects. Antidiabetic agent.Product Specifications
Molecular Weight
514.21
Formula
C21H12Cl4N2O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide
CAS Number
315224-26-1
PubChem ID
10229498
InChI Key
NMRWDFUZLLQSBN-UHFFFAOYSA-N
SMILES
O=S(=O)(NC1=CC(Cl)=C(OC2=CN=C3C=CC=CC3=C2)C(Cl)=C1)C4=CC=C(Cl)C=C4Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.57 | 5 | |
| Ethanol | 2.57 | 5 |
Preparing Stock Solutions
for INT 131
The following data is based on the product molecular weight 514.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 38.89 mL | 194.47 mL | 388.95 mL |
| 0.25 mM | 7.78 mL | 38.89 mL | 77.79 mL |
| 0.5 mM | 3.89 mL | 19.45 mL | 38.89 mL |
| 2.5 mM | 0.78 mL | 3.89 mL | 7.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Motani INT131: a selective modulator of PPARγ. J.Mol.Biol. 2009 PMID: 19452630
- Frkic Structure-activity relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) analogs for PPARγ-targeted antidiabetics. J.Med.Chem. 2017 PMID: 28485590
Product Specific Notices for INT 131
For research use only
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