Indomethacin
Tocris Bioscience, part of Bio-Techne | Catalog # 1708
Cyclooxygenase inhibitor (COX-1 > COX-2)
Key Product Details
Description
Cyclooxygenase inhibitor (COX-1 > COX-2)
Product Description
Indomethacin is a cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.Product Specifications
Molecular Weight
357.79
Formula
C19H16ClNO4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
CAS Number
53-86-1
PubChem ID
3715
InChI Key
CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES
COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.78 | 100 | |
| Ethanol | 17.89 | 50 with gentle warming |
Preparing Stock Solutions
for Indomethacin
The following data is based on the product molecular weight 357.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.79 mL | 13.97 mL | 27.95 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.59 mL |
| 10 mM | 0.28 mL | 1.40 mL | 2.79 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
- Shen and Winter Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 1977 PMID: 343530
- Walters and Willoughby Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 1965 PMID: 5849618
- Palomer Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 2002 PMID: 11906281
Product Specific Notices for Indomethacin
For research use only
Loading...
Loading...