Indomethacin

Name: Indomethacin
Brand: Tocris Bioscience
SKU: 1708

Tocris Bioscience, part of Bio-Techne | Catalog # 1708

Citations (52)

COA / SDS

Cyclooxygenase inhibitor (COX-1 > COX-2)

Key Product Details

Description:	Cyclooxygenase inhibitor (COX-1 > COX-2)
Chemical Name:	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Purity:	≥98% (HPLC)
Molecular Weight:	357.79

View Full Technical Details for Indomethacin

Technical Data
Citations

Biological Activity for Indomethacin

Indomethacin is a cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC₅₀ values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.

Technical Data for Indomethacin

M. Wt	357.79
Formula	C₁₉H₁₆ClNO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	53-86-1
PubChem ID	3715
InChi Key	CGIGDMFJXJATDK-UHFFFAOYSA-N
Smiles	COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Indomethacin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	17.89	50 with gentle warming
	DMSO	35.78	100

Preparing Stock Solutions for Indomethacin

The following data is based on the product molecular weight 357.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.97 mL	27.95 mL
5 mM	0.56 mL	2.79 mL	5.59 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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Reconstitution Calculator

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References for Indomethacin

References are publications that support the biological activity of the product.

Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
Shen and Winter Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 1977 PMID: 343530
Walters and Willoughby Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 1965 PMID: 5849618
Palomer Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 2002 PMID: 11906281