Indirubin-3'-oxime

Tocris Bioscience, part of Bio-Techne | Catalog # 1813

GSK-3β inhibitor; also inhibits cdks and other protein kinases
Discontinued Product
1813 has been discontinued. View all GSK-3 Inhibitors products.

Key Product Details

Description

GSK-3β inhibitor; also inhibits cdks and other protein kinases

Alternative Names

Indirubin-3'-monoxime

View all GSK-3 Inhibitors »

Product Description

Indirubin-3'-oxime is a inhibitor of GSK-3β (IC50 = 190 nM) and cyclin dependent kinases (cdks; IC50 values are 0.05, 0.18 and 0.25-0.5 βM for cdk9, cdk1 and cdk2, respectively). Also reported to inhibit AMPK, LCK and SGK. Inhibits cdk5- and GSK-3β-mediated tau phosphorylation. Induces cell cycle arrest and inhibits cell proliferation.

Product Specifications

Molecular Weight

277.28

Formula

C16H11N3O2

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

CAS Number

160807-49-8

PubChem ID

5326739

InChI Key

LDEWQRSYYHTQRA-UHFFFAOYSA-N

SMILES

O\N=C1C2=CC=CC=C2NC/1=C1\C(=O)NC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.73 100
Ethanol 27.73 100

Preparing Stock Solutions for Indirubin-3'-oxime

The following data is based on the product molecular weight 277.28

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.06 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.80 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for Indirubin-3'-oxime

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Indirubin-3'-oxime

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.