INCB 3284 dimesylate
Tocris Bioscience, part of Bio-Techne | Catalog # 4306
Selective CCR2 antagonist
Key Product Details
Description
Selective CCR2 antagonist
Product Description
INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μ M). Orally bioavailable.Product Specifications
Molecular Weight
712.76
Formula
C26H31F3N4O4.2CH4O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate
CAS Number
887401-93-6
PubChem ID
11679268
InChI Key
PNPNUHKICDECDH-SEBNIYPMSA-N
SMILES
O=C(NCC(N[C@@H]2CCN([C@H]3CC[C@](C4=CC=C(OC)N=C4)(O)CC3)C2)=O)C1=CC(C(F)(F)F)=CC=C1.CS(=O)(O)=O.CS(=O)(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 71.28 | 100 | |
| DMSO | 71.28 | 100 |
Preparing Stock Solutions
for INCB 3284 dimesylate
The following data is based on the product molecular weight 712.76
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.40 mL | 7.01 mL | 14.03 mL |
| 5 mM | 0.28 mL | 1.40 mL | 2.81 mL |
| 10 mM | 0.14 mL | 0.70 mL | 1.40 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.28 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xue Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist. ACS.Med.Chem.Lett. 2011 PMID: 24900329
Product Specific Notices for INCB 3284 dimesylate
For research use only
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