ICA 069673

Name: ICA 069673
Brand: Tocris Bioscience
SKU: 4305
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4305

(1)

Citations (13)

COA / SDS

KV7.2/KV7.3 channel opener

Key Product Details

Description:	K_V7.2/K_V7.3 channel opener
Chemical Name:	N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	269.63

View Full Technical Details for ICA 069673

Technical Data
Citations / Reviews (1)

Biological Activity for ICA 069673

ICA 069673 is a selective K_V7.2/K_V7.3 (KCNQ2/3) channel opener (EC₅₀ = 0.69 μM). Exhibits 20-fold selectivity for K_V7.2/K_V7.3 over K_V7.3/K_V7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Compound Libraries for ICA 069673

ICA 069673 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ICA 069673

M. Wt	269.63
Formula	C₁₁H₆ClF₂N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	582323-16-8
PubChem ID	10149311
InChi Key	IIBSHMFXVWTQSJ-UHFFFAOYSA-N
Smiles	ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ICA 069673

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.96	100
	ethanol	6.74	25

Preparing Stock Solutions for ICA 069673

The following data is based on the product molecular weight 269.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.54 mL	37.09 mL
5 mM	0.74 mL	3.71 mL	7.42 mL
10 mM	0.37 mL	1.85 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for ICA 069673

References are publications that support the biological activity of the product.

Provence The novel K_v7.2/K_v7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility. J.Pharmacol.Exp.Ther. 2015 PMID: 26087697
Amato N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2011 PMID: 24900334