HTH 01-015
Tocris Bioscience, part of Bio-Techne | Catalog # 5622
Potent and selective NUAK1 inhibitor
Product Description
HTH 01-015 is a potent and selective NUAK1 inhibitor (IC50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells in vitro, to a similar extent as NUAK1 knockdown models.Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
468.55
Formula
C26H28N8O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
CAS Number
1613724-42-7
PubChem ID
78357766
InChI Key
CHSDJDLAKKAWCI-UHFFFAOYSA-N
SMILES
O=C1N(C)C2=C(N=C(NC3=CN(C4CCNCC4)N=C3)N=C2C)N(C)C5=CC6=CC=CC=C6C=C51
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.85 | 100 | |
| Ethanol | 46.85 | 100 |
Preparing Stock Solutions
for HTH 01-015
The following data is based on the product molecular weight 468.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.67 mL | 21.34 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Banerjee Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 PMID: 24171924
Product Specific Notices for HTH 01-015
For research use only
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