HS 014

Tocris Bioscience, part of Bio-Techne | Catalog # 1831

COA / SDS

Selective MC4 receptor antagonist

Key Product Details

Description:	Selective MC₄ receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1563.77

View Full Technical Details for HS 014

Technical Data
Citations

Biological Activity for HS 014

HS 014 is a potent and selective melanocortin MC₄ receptor antagonist (K_i values are 3.16, 108, 54.4 and 694 nM for cloned human MC₄, MC₁, MC₃ and MC₅ receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.

Technical Data for HS 014

M. Wt	1563.77
Formula	C₇₁H₉₄N₂₀O₁₇S₂
Single Letter Sequence	CEHXRWGCPPKD (Modifications: Cys-1 = N-terminal Ac, X = D-2-Nal, Asp-12 = C-terminal amide, Disulfide bridge: 1-8)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	207678-81-7
PubChem ID	24821295
InChi Key	BRGDPINZISNYJL-VMAVSDBDSA-N
Smiles	CC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HS 014

Solubility

Soluble to 1mg/ml in water

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References for HS 014

References are publications that support the biological activity of the product.

Schioth Discovery of novel melanocortin₄ receptor selective MSH analogues. Br.J.Pharmacol. 1998 PMID: 9630346
Whitaker and Reye Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 2008 PMID: 18082228
Bellasio Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 2003 PMID: 14660013