HQL 79
Tocris Bioscience, part of Bio-Techne | Catalog # 3530
Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Key Product Details
Description
Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Product Description
HQL 79 is an orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.Product Specifications
Molecular Weight
377.48
Formula
C22H27N5O
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine
CAS Number
162641-16-9
PubChem ID
6540277
InChI Key
TZQGXAHOROZEKN-UHFFFAOYSA-N
SMILES
C1(CCCN2CCC(OC(C4=CC=CC=C4)C3=CC=CC=C3)CC2)=NN=NN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.44 | 25 |
Preparing Stock Solutions
for HQL 79
The following data is based on the product molecular weight 377.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.60 mL | 52.98 mL | 105.97 mL |
| 1.25 mM | 2.12 mL | 10.60 mL | 21.19 mL |
| 2.5 mM | 1.06 mL | 5.30 mL | 10.60 mL |
| 12.5 mM | 0.21 mL | 1.06 mL | 2.12 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Matsushita Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 1998 PMID: 9804057
- Mohri Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 2006 PMID: 16624958
- Aritake Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 2006 PMID: 16547010
Product Specific Notices for HQL 79
For research use only
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