HOE 140

Tocris Bioscience, part of Bio-Techne | Catalog # 3014

(1)

Citations (49)

COA / SDS

Potent and selective B2 antagonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective B2 antagonist

Alternative Names

Icatibant

View all Bradykinin Receptor Antagonists »

Product Description

HOE 140 is a potent and selective bradykinin B₂ receptor antagonist (pA₂ = 9.04). Also inhibits aminopeptidase N (K_i = 9.1 μM).

Product Specifications

Molecular Weight

1304.52

Formula

C₅₉H₈₉N₁₉O₁₃S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

130308-48-4

PubChem ID

90488794

InChI Key

QURWXBZNHXJZBE-JNFYKTHFSA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1C3CCCCC3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Feletou Agonistic and antagonistic properties of the bradykinin B₂ receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 1994 PMID: 8075888
Bawolak The bradykinin B₂ receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B₁ and angiotensin receptors. Eur.J.Pharmacol. 2006 PMID: 17026984
Hock Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 1991 PMID: 1364851