HEMTAC 26
Tocris Bioscience, part of Bio-Techne | Catalog # 7940
CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader
Key Product Details
Description
CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader
Product Description
HEMTAC 26 is a potent HSP90-mediated targeting chimera (HEMTAC) that degrades CDK6 and CDK4 (DC50 values are 19 nM and 26 nM; Dmax = 92% and 88% in B16F10 cells, 36h treatment). HEMTAC 26 inhibits growth of a range of cancer cell lines including B16F10 and A375 (IC50 values are 112 nM and 126 nM respectively). Induces cell cycle arrest at G0/G1 phase in B16F10 cells.Product Specifications
Molecular Weight
953.51
Formula
C48H53ClN16O4
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazineacetamide
CAS Number
2821803-61-4
PubChem ID
167312304
InChI Key
VSAXVERDPZMCPX-UHFFFAOYSA-N
SMILES
O=C1C(C(C)=O)=C(C)C2=C(N1C3CCCC3)N=C(NC4=NC=C(N5CCN(CC5)CC(NCC6=CN(CCC#CC7=CN(CC8=NC=C(C)C(OC)=C8C)C9=C7C(Cl)=NC(N)=N9)N=N6)=O)C=C4)N=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 95.35 | 100 |
Preparing Stock Solutions
for HEMTAC 26
The following data is based on the product molecular weight 953.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.05 mL | 5.24 mL | 10.49 mL |
| 5 mM | 0.21 mL | 1.05 mL | 2.10 mL |
| 10 mM | 0.10 mL | 0.52 mL | 1.05 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Targeted protein degradation induced by HEMTACs based on HSP90. J.Med.Chem. 2023 PMID: 36574496
Product Specific Notices for HEMTAC 26
For research use only
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