HEMTAC 26

Name: HEMTAC 26
Brand: Tocris Bioscience
SKU: 7940

Tocris Bioscience, part of Bio-Techne | Catalog # 7940

COA / SDS

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

Key Product Details

Description:	CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader
Chemical Name:	4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazineacetamide
Purity:	≥95% (HPLC)
Molecular Weight:	953.51

View Full Technical Details for HEMTAC 26

Technical Data
Citations

Biological Activity for HEMTAC 26

HEMTAC 26 is a potent HSP90-mediated targeting chimera (HEMTAC) that degrades CDK6 and CDK4 (DC₅₀ values are 19 nM and 26 nM; D_max = 92% and 88% in B16F10 cells, 36h treatment). HEMTAC 26 inhibits growth of a range of cancer cell lines including B16F10 and A375 (IC₅₀ values are 112 nM and 126 nM respectively). Induces cell cycle arrest at G₀/G₁ phase in B16F10 cells.

Technical Data for HEMTAC 26

M. Wt	953.51
Formula	C₄₈H₅₃ClN₁₆O₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2821803-61-4
PubChem ID	167312304
InChi Key	VSAXVERDPZMCPX-UHFFFAOYSA-N
Smiles	O=C1C(C(C)=O)=C(C)C2=C(N1C3CCCC3)N=C(NC4=NC=C(N5CCN(CC5)CC(NCC6=CN(CCC#CC7=CN(CC8=NC=C(C)C(OC)=C8C)C9=C7C(Cl)=NC(N)=N9)N=N6)=O)C=C4)N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HEMTAC 26

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	95.35	100

Preparing Stock Solutions for HEMTAC 26

The following data is based on the product molecular weight 953.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.05 mL	5.24 mL	10.49 mL
5 mM	0.21 mL	1.05 mL	2.10 mL
10 mM	0.10 mL	0.52 mL	1.05 mL
50 mM	0.02 mL	0.10 mL	0.21 mL

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References for HEMTAC 26

References are publications that support the biological activity of the product.

Li Targeted protein degradation induced by HEMTACs based on HSP90. J.Med.Chem. 2023 PMID: 36574496