hCAII Degrader 11

Name: hCAII Degrader 11
Brand: Tocris Bioscience
SKU: 7964

Tocris Bioscience, part of Bio-Techne | Catalog # 7964

COA / SDS

Potent human carbonic anhydrase II Degrader (PROTAC®)

Key Product Details

Description:	Potent human carbonic anhydrase II Degrader (PROTAC^®)
Chemical Name:	4-(Aminosulfonyl)-N-[12-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]dodecyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	639.77

View Full Technical Details for hCAII Degrader 11

Technical Data
Citations

Biological Activity for hCAII Degrader 11

hCAII Degrader 11 is a potent human carbonic anhydrase II (hCAII) Degrader (PROTAC^®; D_max = 100% at 5 nM, DC₅₀ = 0.5 nM).

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Sold with kind permission of Professor Cohen and Professor Burkart, Department of Chemistry and Biochemistry, University of California, USA.

Licensing Information

Sold with kind permission of Professor Cohen and Professor Burkart

Technical Data for hCAII Degrader 11

M. Wt	639.77
Formula	C₃₂H₄₁N₅O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2892306-56-6
PubChem ID	167312395
InChi Key	AZBRPAQQOMDJLZ-UHFFFAOYSA-N
Smiles	O=C(NCCCCCCCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(S(=O)(N)=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for hCAII Degrader 11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	63.98	100

Preparing Stock Solutions for hCAII Degrader 11

The following data is based on the product molecular weight 639.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.56 mL	7.82 mL	15.63 mL
5 mM	0.31 mL	1.56 mL	3.13 mL
10 mM	0.16 mL	0.78 mL	1.56 mL
50 mM	0.03 mL	0.16 mL	0.31 mL

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Reconstitution Calculator

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References for hCAII Degrader 11

References are publications that support the biological activity of the product.

O'Herin Development of human carbonic anhydrase II heterobifunctional degraders J.Med.Chem. 2023 PMID: 36735827