GYKI 53655 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2555

Non-competitive non-NMDA iGluR antagonist
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Key Product Details

Description

Non-competitive non-NMDA iGluR antagonist

View all AMPA Receptor Antagonists »

Product Description

GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.

Product Specifications

Molecular Weight

388.85

Formula

C19H20N4O3.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride

CAS Number

143692-48-2

PubChem ID

126757

InChI Key

ASLCSBBDVWPSQT-UHFFFAOYSA-N

SMILES

CC(N(C(NC)=O)N=C3C4=CC=C(N)C=C4)CC1=C3C=C(OCO2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 38.88 100
DMSO 38.88 100

Preparing Stock Solutions for GYKI 53655 hydrochloride

The following data is based on the product molecular weight 388.85

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.86 mL 25.72 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for GYKI 53655 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GYKI 53655 hydrochloride

For research use only

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