GW 9662

Name: GW 9662
Brand: Tocris Bioscience
SKU: 1508
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1508

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Citations (132)

COA / SDS

Selective covalent PPARγ antagonist

Key Product Details

Description:	Selective covalent PPARγ antagonist
Chemical Name:	2-Chloro-5-nitro-N-phenylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	276.68

View Full Technical Details for GW 9662

Technical Data
Citations / Reviews (1)

Biological Activity for GW 9662

GW 9662 is a selective irreversible PPARγ antagonist (IC₅₀ values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE. Anticancer, inhibits growth of human mammary tumor cell lines.

Compound Libraries for GW 9662

GW 9662 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GW 9662

M. Wt	276.68
Formula	C₁₃H₉N₂O₃Cl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	22978-25-2
PubChem ID	644213
InChi Key	DNTSIBUQMRRYIU-UHFFFAOYSA-N
Smiles	[O-][N+](=O)C1=CC(C(=O)NC2=CC=CC=C2)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 9662

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	6.92	25 with gentle warming
	DMSO	27.67	100

Preparing Stock Solutions for GW 9662

The following data is based on the product molecular weight 276.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.07 mL	36.14 mL
5 mM	0.72 mL	3.61 mL	7.23 mL
10 mM	0.36 mL	1.81 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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Reconstitution Calculator

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References for GW 9662

References are publications that support the biological activity of the product.

Leesnitzer Functional consequences of cysteine modification in the ligand binding sites of peroxisone proliferator activated receptors by GW9662. Biochemistry 2002 PMID: 12022867
Seargent GW9662, a potent antaognist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation. Br.J.Pharmacol. 2004 PMID: 15533890
Bendixen IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1. Proc.Natl.Acad.Sci.U.S.A. 2001 PMID: 11226258