GW 1929 hydrochloride

Name: GW 1929 hydrochloride
Brand: Tocris Bioscience
SKU: 1664

Tocris Bioscience, part of Bio-Techne | Catalog # 1664

Citations (3)

COA / SDS

Selective PPARγ agonist. Orally active

Key Product Details

Description:	Selective PPARγ agonist. Orally active
Chemical Name:	N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	532.03

View Full Technical Details for GW 1929 hydrochloride

Technical Data
Citations

Biological Activity for GW 1929 hydrochloride

GW 1929 hydrochloride is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC₅₀ values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GW 1929 hydrochloride

M. Wt	532.03
Formula	C₃₀H₂₉N₃O₄.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1217466-21-1
PubChem ID	76453663
InChi Key	KXNKIKXTGRMLEY-UHFFFAOYSA-N
Smiles	Cl.CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C2=CC=CC=C2)C(O)=O)C=C1)C1=NC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 1929 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	49.56	100 with gentle warming
	water	26.6	50

Preparing Stock Solutions for GW 1929 hydrochloride

The following data is based on the product molecular weight 532.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.40 mL	18.80 mL
5 mM	0.38 mL	1.88 mL	3.76 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for GW 1929 hydrochloride

References are publications that support the biological activity of the product.

Nugent Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation. Mol.Endocrinol. 2001 PMID: 11579205
Way Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J.Biol.Chem. 2001 PMID: 11373275
Brown A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 1999 PMID: 10389847