GT 949
Tocris Bioscience, part of Bio-Techne | Catalog # 6578
Potent and selective positive allosteric modulator of EAAT2
Key Product Details
Description
Potent and selective positive allosteric modulator of EAAT2
Product Description
GT 949 is a potent and selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Neuroprotective in an in vitro model of excitotoxicity.Product Specifications
Molecular Weight
527.66
Formula
C30H37N7O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
CAS Number
460330-27-2
PubChem ID
3195790
InChI Key
ZVWPOIUAPXDLMB-UHFFFAOYSA-N
SMILES
COC1=CC=C2NC(C(C(C3=NN=NN3CCC4=CC=CC=C4)N5CCN(C6CCCCC6)CC5)=CC2=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.77 | 100 |
Preparing Stock Solutions
for GT 949
The following data is based on the product molecular weight 527.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.90 mL | 9.48 mL | 18.95 mL |
| 5 mM | 0.38 mL | 1.90 mL | 3.79 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.90 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Falcucci Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model. ACS Chem.Neurosci. 2019 PMID: 31257852
- Kortagere Identification of novel allosteric modulators of glutamate transporter EAAT2. ACS Chem.Neurosci. 2018 PMID: 29140675
Product Specific Notices for GT 949
For research use only
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