GSK 5959

Name: GSK 5959
Brand: Tocris Bioscience
SKU: 5385

Tocris Bioscience, part of Bio-Techne | Catalog # 5385

Citations (3)

COA / SDS

Potent and selective BRPF1 inhibitor

Discontinued Product

5385 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description:	Potent and selective BRPF1 inhibitor
Chemical Name:	N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	394.47

View Full Technical Details for GSK 5959

Technical Data
Citations

Biological Activity for GSK 5959

GSK 5959 is a potent and selective BRPF1 bromodomain inhibitor (IC₅₀ = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 5959 is reviewed on the chemical probes website.

Technical Data for GSK 5959

M. Wt	394.47
Formula	C₂₂H₂₆N₄O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	901245-65-6
PubChem ID	15990224
InChi Key	LTUGYAOMCKNTGG-UHFFFAOYSA-N
Smiles	CN(C1=CC(NC(C4=C(OC)C=CC=C4)=O)=C(N3CCCCC3)C=C1N2C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GSK 5959

References are publications that support the biological activity of the product.

Demont 1,3-dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 2014 PMID: 25408830