GSK 4112

Name: GSK 4112
Brand: Tocris Bioscience
SKU: 3663

Tocris Bioscience, part of Bio-Techne | Catalog # 3663

Citations (11)

COA / SDS

Selective Rev-Erbα agonist

Key Product Details

Description:	Selective Rev-Erbα agonist
Alternative Names:	SR 6452
Chemical Name:	1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Purity:	≥98% (HPLC)
Molecular Weight:	396.89

View Full Technical Details for GSK 4112

Technical Data
Citations

Biological Activity for GSK 4112

GSK 4112 is a selective Rev-Erbα agonist (EC₅₀ = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.

Compound Libraries for GSK 4112

GSK 4112 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 4112

M. Wt	396.89
Formula	C₁₈H₂₁ClN₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1216744-19-2
PubChem ID	50905018
InChi Key	WYSLOKHVFKLWOU-UHFFFAOYSA-N
Smiles	CC(C)(C)OC(CN(CC2=CC=C(Cl)C=C2)CC1=CC=C([N+]([O-])=O)S1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 4112

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.92	25

Preparing Stock Solutions for GSK 4112

The following data is based on the product molecular weight 396.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.08 mL	50.39 mL	100.78 mL
1.25 mM	2.02 mL	10.08 mL	20.16 mL
2.5 mM	1.01 mL	5.04 mL	10.08 mL
12.5 mM	0.20 mL	1.01 mL	2.02 mL

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Reconstitution Calculator

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References for GSK 4112

References are publications that support the biological activity of the product.

Kojetin Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 2011 PMID: 21043485
Meng Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 2008 PMID: 18946026