GSK 2239633A

Name: GSK 2239633A
Brand: Tocris Bioscience
SKU: 7071

Tocris Bioscience, part of Bio-Techne | Catalog # 7071

COA / SDS

Potent CCR4 antagonist

Key Product Details

Description:	Potent CCR4 antagonist
Chemical Name:	N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide
Purity:	≥98% (HPLC)
Molecular Weight:	549.06

View Full Technical Details for GSK 2239633A

Technical Data
Citations

Biological Activity for GSK 2239633A

GSK 2239633A is a potent CCR4 antagonist (pIC₅₀ = 7.83 in a ³⁵S-GTPγS competition assay). Inhibits thymus activation-regulated chemokine (TARC) -induced F-actin polymerization in human whole blood.

Technical Data for GSK 2239633A

M. Wt	549.06
Formula	C₂₄H₂₅ClN₄O₅S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1240516-71-5
PubChem ID	46861584
InChi Key	YTEVTHHGQMUPHC-UHFFFAOYSA-N
Smiles	COC1=C2C(NS(=O)(C3=CC=C(S3)Cl)=O)=NN(C2=CC=C1)CC4=CC(CNC(C(C)(O)C)=O)=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 2239633A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.91	100

Preparing Stock Solutions for GSK 2239633A

The following data is based on the product molecular weight 549.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.82 mL	9.11 mL	18.21 mL
5 mM	0.36 mL	1.82 mL	3.64 mL
10 mM	0.18 mL	0.91 mL	1.82 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for GSK 2239633A

References are publications that support the biological activity of the product.

Procopiou Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation. Bioorg.Med.Chem.Lett. 2012 PMID: 22437117