GSK 2194069
Tocris Bioscience, part of Bio-Techne | Catalog # 5303
Potent human fatty acid synthase (hFASN) inhibitor
Key Product Details
Description
Potent human fatty acid synthase (hFASN) inhibitor
Product Description
GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor (IC50 = 7.7 nM); inhibits hFAS β-ketoacyl reductase activity. Inhibits lipid synthesis and attenuates proliferation of A549 non-small-cell lung cancer cells (EC50 = 15 nM) in vitro. GSK 2194069 also inhibits infection by SARS-CoV-2 (EC50 = 0.9 nM) in vitro.Product Specifications
Molecular Weight
428.48
Formula
C25H24N4O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS Number
1332331-08-4
PubChem ID
67376285
InChI Key
AQTPWCUIYUOEMG-INIZCTEOSA-N
SMILES
O=C1NN=C(C[C@@H]2CCN(C(C3CC3)=O)C2)N1C4=CC=C(C5=CC=C(OC=C6)C6=C5)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.85 | 100 | |
| Ethanol | 8.57 | 20 |
Preparing Stock Solutions
for GSK 2194069
The following data is based on the product molecular weight 428.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chu Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat.Metab. 2021 PMID: 34580494
- Hardwicke A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat.Chem.Biol. 2014 PMID: 25086508
Product Specific Notices for GSK 2194069
For research use only
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