GRP (human)

Name: GRP (human)
Brand: Tocris Bioscience
SKU: 1789

Tocris Bioscience, part of Bio-Techne | Catalog # 1789

Citations (7)

COA / SDS

Endogenous GRP receptor agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous GRP receptor agonist

Alternative Names

Gastrin-releasing peptide (human)

View all Bombesin Receptor Agonists »

Product Description

GRP (human) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Product Specifications

Molecular Weight

2859.40

Formula

C₁₃₀H₂₀₄N₃₈O₃₁S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

93755-85-2

PubChem ID

16143985

InChI Key

PUBCCFNQJQKCNC-XKNFJVFFSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Woodruff Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 1996 PMID: 8602736
Dudai Neurobiology: Fear thou not. Nature 2003 PMID: 12540884
Shumyatsky Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 2002 PMID: 12526815
Benya Expression and characterization of cloned human bombesin receptors. Mol.Pharmacol. 1995 PMID: 7838118