Granisetron hydrochloride

Name: Granisetron hydrochloride
Brand: Tocris Bioscience
SKU: 2903

Tocris Bioscience, part of Bio-Techne | Catalog # 2903

Citations (17)

COA / SDS

5-HT3 antagonist

Key Product Details

Description:	5-HT₃ antagonist
Alternative Names:	BRL 43694
Chemical Name:	1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	348.87

View Full Technical Details for Granisetron hydrochloride

Technical Data
Citations

Biological Activity for Granisetron hydrochloride

Granisetron hydrochloride is a 5-HT₃ receptor antagonist that possesses potent antiemetic activity.

Technical Data for Granisetron hydrochloride

M. Wt	348.87
Formula	C₁₈H₂₄N₄O.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	107007-99-8
PubChem ID	65264
InChi Key	QYZRTBKYBJRGJB-UHFFFAOYSA-N
Smiles	O=C(C3=NN(C)C4=C3C=CC=C4)NC1CC(N2C)CCCC2C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Granisetron hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	34.89	100
	DMSO	3.49	10

Preparing Stock Solutions for Granisetron hydrochloride

The following data is based on the product molecular weight 348.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.33 mL	28.66 mL
5 mM	0.57 mL	2.87 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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Reconstitution Calculator

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References for Granisetron hydrochloride

References are publications that support the biological activity of the product.

Plosker and Goa Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 1991 PMID: 1723376
Martin Anti-emetic effect of ondans. and granis. after exposure to mixed neutron and gamma irradiation. Rad.Res.
Sanger and Nelson Selective and functional 5-hydroxytryptamine₃ receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 1989 PMID: 2540014