GR 64349

Name: GR 64349
Brand: Tocris Bioscience
SKU: 1668

Tocris Bioscience, part of Bio-Techne | Catalog # 1668

Citations (22)

COA / SDS

Potent, selective NK2 agonist

Key Product Details

Description:	Potent, selective NK₂ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	921.12

View Full Technical Details for GR 64349

Technical Data
Citations

Biological Activity for GR 64349

GR 64349 is a potent and selective tachykinin NK₂ receptor agonist (EC₅₀ = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK₁ and NK₃ receptors respectively. Active in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GR 64349

M. Wt	921.12
Formula	C₄₂H₆₈N₁₀O₁₁S
Single Letter Sequence	KDSFVGLM (Modifications: Leu-7 = R-γ-lactam-Leu, Met-8 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	137593-52-3
PubChem ID	5311135
InChi Key	HVUNRXRFMQDMBO-BPZYSUIOSA-N
Smiles	[H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NC1CCN([C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GR 64349

Solubility

Soluble to 1mg/ml in water

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References for GR 64349

References are publications that support the biological activity of the product.

Chizh Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK₁ and NK₂ receptors in the rat spinal cord. Br.J.Pharmacol. 1995 PMID: 7582497
Deal Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J.Med.Chem. 1992 PMID: 1331460
Chang Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J.Pharmacol.Exp.Ther. 2000 PMID: 10871306