GR 144053 trihydrochloride

Name: GR 144053 trihydrochloride
Brand: Tocris Bioscience
SKU: 1263

Tocris Bioscience, part of Bio-Techne | Catalog # 1263

Citations (14)

COA / SDS

Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic

Key Product Details

Description:	Glycoprotein IIb/IIIa (integrin α_IIbβ₃) receptor antagonist. Antithrombotic
Chemical Name:	4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	454.83

View Full Technical Details for GR 144053 trihydrochloride

Technical Data
Citations

Biological Activity for GR 144053 trihydrochloride

GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC₅₀ = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo.

Technical Data for GR 144053 trihydrochloride

M. Wt	454.83
Formula	C₁₈H₂₇N₅O₂.3HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	1215333-48-4
PubChem ID	107895
InChi Key	GFZHNFOGCMEYTA-UHFFFAOYSA-N
Smiles	Cl.Cl.Cl.NC(=N)C1=CC=C(C=C1)N1CCN(CC1)C1CCN(CC(O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GR 144053 trihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	45.48	100

Preparing Stock Solutions for GR 144053 trihydrochloride

The following data is based on the product molecular weight 454.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	10.99 mL	21.99 mL
5 mM	0.44 mL	2.20 mL	4.40 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for GR 144053 trihydrochloride

References are publications that support the biological activity of the product.

Matsuno GR 144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster. Br.J.Pharmacol. 1997 PMID: 9480031
Matsuno Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a GPIIb/IIIa antagonist with special reference to the role of platelet microaggregates. Br.J.Pharmacol. 1999 PMID: 10455258
Eldred Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad spectrum antithrombotic agent. J.Med.Chem. 1994 PMID: 7966149