GR 127935 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1477
Potent and selective 5-HT1B and 5-HT1D antagonist
Key Product Details
Description
Potent and selective 5-HT1B and 5-HT1D antagonist
Product Description
GR 127935 hydrochloride is a potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration.Licensing Information
Sold under licenseProduct Specifications
Molecular Weight
534.06
Formula
C29H31N5O3.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride
CAS Number
148642-42-6
PubChem ID
11497466
InChI Key
SRVVUYIJVBLEJI-UHFFFAOYSA-N
SMILES
Cl.COC1=C(C=C(NC(=O)C2=CC=C(C=C2)C2=CC=C(C=C2C)C2=NOC(C)=N2)C=C1)N1CCN(C)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 49.76 | 100 |
Preparing Stock Solutions
for GR 127935 hydrochloride
The following data is based on the product molecular weight 534.06
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.87 mL | 9.36 mL | 18.72 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.87 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- De Vries Blockade of porcine carotid vascular response to sumatr. by GR 127935, a selective 5-HT1D receptor antagonist. Br.J.Pharmacol. 1996 PMID: 8733580
- Knobelman Genetic regulation of extracellular serotonin by 5-hydroxytryptamine1A and 5-hydroxytryptamine1B autoreceptors in different brain regions of the mouse. J.Pharmacol.Exp.Ther. 2001 PMID: 11504805
- Clitherow Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzalides as the first selective 5-HT1D antagonists. J.Med.Chem. 1994 PMID: 8057272
Product Specific Notices for GR 127935 hydrochloride
For research use only
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