GPP 78 hydrochloride

Name: GPP 78 hydrochloride
Brand: Tocris Bioscience
SKU: 4835
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4835

(1)

Citations (28)

COA / SDS

NAMPT inhibitor; also induces autophagy

Discontinued Product

4835 has been discontinued. View all NAMPT Inhibitors products.

Key Product Details

Description:	NAMPT inhibitor; also induces autophagy
Chemical Name:	N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	476.01

View Full Technical Details for GPP 78 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for GPP 78 hydrochloride

GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC₅₀ values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.

Technical Data for GPP 78 hydrochloride

M. Wt	476.01
Formula	C₂₇H₂₉N₅O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	90488976
InChi Key	WNZSQRVUGCAYDC-UHFFFAOYSA-N
Smiles	O=C(NC3=C(C4=CC=CC=C4)C=CC=C3)CCCCCCCN1N=NC(C2=CC=CN=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GPP 78 hydrochloride

References are publications that support the biological activity of the product.

Colombano A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J.Med.Chem. 2010 PMID: 19961183

GPP 78 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4835

Key Product Details

Biological Activity for GPP 78 hydrochloride

Technical Data for GPP 78 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GPP 78 hydrochloride

Product Documents for GPP 78 hydrochloride

COA

Certificate of Analysis

SDS

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