GPBAR-A
Tocris Bioscience, part of Bio-Techne | Catalog # 4478
GPBA receptor (TGR5) agonist
Product Description
GPBAR-A is a gPBA receptor agonist. Upregulates GLP-1 secretion from intestinal cultures. Increases MQAE-fluorescence suggesting a decrease in intracellular chloride concentration in gallbladder epithelial cells.Product Specifications
Molecular Weight
484.37
Formula
C23H15F7N2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one
CAS Number
877052-79-4
PubChem ID
11656002
InChI Key
ZIXNJVGTAXRKAP-UHFFFAOYSA-N
SMILES
O=C(CO3)N(CC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)CC1=C3N=CC=C1C2=C(F)C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.44 | 100 | |
| Ethanol | 9.69 | 20 |
Preparing Stock Solutions
for GPBAR-A
The following data is based on the product molecular weight 484.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.32 mL | 20.65 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.13 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Keitel The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009 PMID: 19582812
- Parker Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. Br.J.Pharmacol. 2012 PMID: 21718300
Product Specific Notices for GPBAR-A
For research use only
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