Go 6976

Product Description

Go 6976 is a potent protein kinase C (PKC) inhibitor (IC₅₀ = 7.9 nM). Discriminates between Ca²⁺-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC₅₀ values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC₅₀ > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC₅₀ values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.

Solubility

Preparing Stock Solutions for Go 6976

The following data is based on the product molecular weight 378.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.42 mL	132.12 mL	264.25 mL
0.5 mM	5.28 mL	26.42 mL	52.85 mL
1 mM	2.64 mL	13.21 mL	26.42 mL
5 mM	0.53 mL	2.64 mL	5.28 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Stolz Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells. Cancer Res. 2009 PMID: 19366805
• Grandage Go6976 is a potent inhibitor of JAK2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells. Br.J.Haematol. 2006 PMID: 16956345
• Rennecke Immunological demonstration of protein kinase Cμ in murine tissues and various cell lines. Eur.J.Biochem. 1996 PMID: 8973662
• Behrens Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. J.Neurochem. 1999 PMID: 10037462
• Martiny-Baron Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976 J.Biol.Chem. 1993 PMID: 8486620