GNTI dihydrochloride

Name: GNTI dihydrochloride
Brand: Tocris Bioscience
SKU: 1282
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1282

(1)

Citations (11)

COA / SDS

Potent, selective κ antagonist

Discontinued Product

1282 has been discontinued. View all Kappa Opioid Receptor Antagonists products.

Key Product Details

Description:	Potent, selective κ antagonist
Chemical Name:	5'-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan dihydrochloride
Purity:	≥96% (HPLC)
Molecular Weight:	544.48

View Full Technical Details for GNTI dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for GNTI dihydrochloride

GNTI dihydrochloride is a highly potent κ opioid receptor antagonist (K_i = 0.18 nM for human cloned κ receptors expressed in CHO cells). Displays 208- and 799-fold selectivity over μ and δ receptors respectively. Reduces feeding behavior in rats with a much higher potency (300-30,000-fold) and a shorter duration of action than nor-binaltorphimine (Cat.No. 0347).

Technical Data for GNTI dihydrochloride

M. Wt	544.48
Formula	C₂₇H₂₉N₅O₃.2HCl
Storage	Desiccate at -20°C
Purity	≥96% (HPLC)
CAS Number	351183-88-5
PubChem ID	90479777
InChi Key	GJPIMNXJPMPQHK-CVVXFVLRSA-N
Smiles	OC3=CC=C2CC([C@@]5(O)[C@@]4(CC8)C2=C3O[C@H]4C(NC7=C6C=C(NC=N)C=C7)=C6C5)N8CC1CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GNTI dihydrochloride

References are publications that support the biological activity of the product.

Jones Mutational evidence for a common κ antagonist binding pocket in the wild type κ and mutant μ[K303E] opioid receptors. J.Med.Chem. 1998 PMID: 9836606
Jones and Portoghese 5'-Guanidinonaltrindole, a highly selective and potent κ-opioid receptor antagonist. Eur.J.Pharmacol. 2000 PMID: 10822054
Jewett The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats. Brain Res. 2001 PMID: 11478923

GNTI dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1282

Key Product Details

Biological Activity for GNTI dihydrochloride

Technical Data for GNTI dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GNTI dihydrochloride

Product Documents for GNTI dihydrochloride

COA

Certificate of Analysis

SDS

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