GNE 9278
Tocris Bioscience, part of Bio-Techne | Catalog # 6369
Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
Key Product Details
Description
Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
Product Description
GNE 9278 is a positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine.Product Specifications
Molecular Weight
429.54
Formula
C21H27N5O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide
CAS Number
901230-11-3
PubChem ID
22432385
InChI Key
OKXCVUICUUOADN-UHFFFAOYSA-N
SMILES
OC(N1C2=NC(CCC)=N1)=C(C(C)=N2)N[S](=O)(C3=CC=C(C4CCCCC4)C=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.95 | 100 |
Preparing Stock Solutions
for GNE 9278
The following data is based on the product molecular weight 429.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. 2017 PMID: 28457974
Product Specific Notices for GNE 9278
For research use only
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