GLYX 13

Name: GLYX 13
Brand: Tocris Bioscience
SKU: 3406

Tocris Bioscience, part of Bio-Techne | Catalog # 3406

Citations (10)

COA / SDS

NMDA partial agonist; acts at the glycine site

Discontinued Product

3406 has been discontinued. View all NMDA Receptor Agonists products.

Key Product Details

Description:	NMDA partial agonist; acts at the glycine site
Alternative Names:	Rapastinel
Purity:	≥95% (HPLC)
Molecular Weight:	413.47

View Full Technical Details for GLYX 13

Technical Data
Citations

Biological Activity for GLYX 13

GLYX 13 is a NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Also promotes VGF and BDNF release and increases ERK/mTOR signaling. Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant.

Technical Data for GLYX 13

M. Wt	413.47
Formula	C₁₈H₃₁N₅O₆
Single Letter Sequence	TPPT (Modifications: Thr-4 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	117928-94-6
PubChem ID	14539800
InChi Key	GIBQQARAXHVEGD-BSOLPCOYSA-N
Smiles	[H]N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GLYX 13

References are publications that support the biological activity of the product.

Shen ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice. Transl.Psychiatry 2022 PMID: 36550125
Wood Antinociceptive action of GLYX-13: a N-MthD.-aspartate receptor glycine site partial agonist. Neuroreport. 2008 PMID: 18580579
Burgdorf The N-MthD.-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol.Aging 2009 PMID: 19446371
Moskal GLYX-13: A monoclonal antibody-derived peptide that acts as an N-MthD.-aspartate receptor modulator. Neuropharmacology 2005 PMID: 16051282

GLYX 13

Tocris Bioscience, part of Bio-Techne | Catalog # 3406

Key Product Details

Biological Activity for GLYX 13

Technical Data for GLYX 13

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GLYX 13

Product Documents for GLYX 13

COA

Certificate of Analysis

SDS

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