Glycyl-H 1152 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2485
Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
Key Product Details
Description
Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
Product Description
Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.Product Specifications
Molecular Weight
449.40
Formula
C18H24N4O3S.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
CAS Number
913844-45-8
PubChem ID
56972177
InChI Key
ILDBNQGLZFSHQZ-UTLKBRERSA-N
SMILES
CC1=CN=CC2=C1C(S(N3CCCN(C(CN)=O)C[C@@H]3C)(=O)=O)=CC=C2.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.94 | 100 | |
| DMSO | 22.47 | 50 |
Preparing Stock Solutions
for Glycyl-H 1152 dihydrochloride
The following data is based on the product molecular weight 449.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.13 mL | 22.25 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tamura Development of specific Rho-kinase inhibitors and their clinical application. Biochim.Biophys.Acta 2005 PMID: 16213195
Product Specific Notices for Glycyl-H 1152 dihydrochloride
For research use only
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