GLPG 0974
Tocris Bioscience, part of Bio-Techne | Catalog # 5621
Potent FFA2 (GPR43) antagonist
Key Product Details
Description
Potent FFA2 (GPR43) antagonist
Product Description
GLPG 0974 is a potent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.Product Specifications
Molecular Weight
485.00
Formula
C25H25ClN2O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid
CAS Number
1391076-61-1
PubChem ID
57520598
InChI Key
MPMKMQHJHDHPBE-RUZDIDTESA-N
SMILES
O=C(N1[C@](C(N(CC2=CC(Cl)=CC=C2)CCCC(O)=O)=O)(C)CC1)C3=CSC4=C3C=CC=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.5 | 100 | |
| Ethanol | 48.5 | 100 |
Preparing Stock Solutions
for GLPG 0974
The following data is based on the product molecular weight 485.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.31 mL | 20.62 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pizzonero Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J.Med.Chem. 2014 PMID: 25380412
Product Specific Notices for GLPG 0974
For research use only
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