GLPG 0187
Tocris Bioscience, part of Bio-Techne | Catalog # 7059
Potent αv integrin inhibitor
Key Product Details
Description
Potent αv integrin inhibitor
Product Description
GLPG 0187 is a potent αv integrin inhibitor (IC50 values are 1.2-3.7 nM). Inhibits osteoclastic bone resorption and angiogenesis in vitro and in vivo. Suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. Induces detachment and necrosis of GL-261 and SMA-560 murine glioma cells.Product Specifications
Molecular Weight
595.71
Formula
C29H37N7O5S
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
3-[[2,5-Dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
CAS Number
1320346-97-1
PubChem ID
53340771
InChI Key
CXHCNOMGODVIKB-VWLOTQADSA-N
SMILES
O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC=C(OC)C=C5)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.96 | 10 |
Preparing Stock Solutions
for GLPG 0187
The following data is based on the product molecular weight 595.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.79 mL | 83.93 mL | 167.87 mL |
| 0.5 mM | 3.36 mL | 16.79 mL | 33.57 mL |
| 1 mM | 1.68 mL | 8.39 mL | 16.79 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Silginer Integrin inhibition promotes atypical anoikis in glioma cells. Cell Death Dis. 2014 PMID: 24457956
- van der Horst, Targeting of αv-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia 2011 PMID: 21677875
Product Specific Notices for GLPG 0187
For research use only
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