Gliocidin

Tocris Bioscience, part of Bio-Techne | Catalog # 8893

IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor, also glioblastoma targeting Nicotinamide mimetic prodrug
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Key Product Details

Description

IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor, also glioblastoma targeting Nicotinamide mimetic prodrug

View all Dehydrogenase Inhibitors »

Product Description

Gliocidin is an IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor. Gliocidin is a nicotinamide-mimetic prodrug that is anabolized into its tumoricidal metabolite, gliocidin-adenine dinucleotide (GAD). Gliocidin kills glioblastoma cells while sparing non-tumour replicative cells. In vivo, Gliocidin penetrates the blood-brain barrier and extends the survival of mice with orthotopic glioblastoma.

Product Specifications

Molecular Weight

204.25

Formula

C10H8N2OS

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-3-Pyridinyl-2-thiophenecarboxamide

CAS Number

62289-81-0

PubChem ID

790407

InChI Key

UPLHUDRMLWWFRE-UHFFFAOYSA-N

SMILES

O=C(NC=1C=NC=CC1)C=2SC=CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.43 100
Ethanol 20.43 100

Preparing Stock Solutions for Gliocidin

The following data is based on the product molecular weight 204.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.90 mL 24.48 mL 48.96 mL
5 mM 0.98 mL 4.90 mL 9.79 mL
10 mM 0.49 mL 2.45 mL 4.90 mL
50 mM 0.10 mL 0.49 mL 0.98 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Gliocidin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Gliocidin

For research use only

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