Givinostat hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6249

Histone deacetylase inhibitor
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Key Product Details

Description

Histone deacetylase inhibitor

Alternative Names

ITF 2357

View all Non-Selective Histone Deacetylase Inhibitors »

Product Description

Givinostat hydrochloride is a histone deacetylase (HDAC) inhibitor (IC50 = 7.5 to 16 nM). At low concentrations reduces release of pro-inflammatory cytokines, including TNFα, INFγ, IL-1α and IL-1β, from LPS stimulated PBMCs in vitro. Exhibits anti-inflammatory effects in vivo. Improves functional recovery and attenuates tissue damage in a mouse model of traumatic brain injury.

Product Specifications

Molecular Weight

457.95

Formula

C24H27N3O4.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

[6-[(Diethylamino)methyl]-2-naphthalenyl]methyl-N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride

CAS Number

199657-29-9

PubChem ID

10095659

InChI Key

QKSGNWJOQMSBEP-UHFFFAOYSA-N

SMILES

CCN(CC1=CC2=C(C=C(C=C2)COC(NC3=CC=C(C(NO)=O)C=C3)=O)C=C1)CC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.8 100

Preparing Stock Solutions for Givinostat hydrochloride

The following data is based on the product molecular weight 457.95

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.92 mL 21.84 mL
5 mM 0.44 mL 2.18 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Product Documents for Givinostat hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Givinostat hydrochloride

For research use only

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