GDC 0941

Name: GDC 0941
Brand: Tocris Bioscience
SKU: 8905

Tocris Bioscience, part of Bio-Techne | Catalog # 8905

COA / SDS

Potent pan-class I PI3 kinase inhibitor

Key Product Details

Description:	Potent pan-class I PI3 kinase inhibitor
Chemical Name:	2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Purity:	≥98% (HPLC)
Molecular Weight:	513.64

View Full Technical Details for GDC 0941

Technical Data
Citations

Biological Activity for GDC 0941

GDC 0941 is a potent pan PI3K inhibitor of class I catalytic subunits p110α, δ, β, and γ (IC₅₀ values are 3, 3, 33 and 75 nM, respectively). GDC 0941 inhibits the PI3K/AKT/mTOR signaling pathways and tumor cell growth in vitro and in vivo. GDC 0941 can be used in stem cell differentiation protocols to generate artery and vein endothelial cells from PSCs. GDC 0941 is orally bioavailable.

Technical Data for GDC 0941

M. Wt	513.64
Formula	C₂₃H₂₇N₇O₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	957054-30-7
PubChem ID	17755052
InChi Key	LHNIIDJUOCFXAP-UHFFFAOYSA-N
Smiles	O=S(=O)(N1CCN(CC=2SC3=C(N=C(N=C3N4CCOCC4)C=5C=CC=C6NN=CC65)C2)CC1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GDC 0941

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.36	100

Preparing Stock Solutions for GDC 0941

The following data is based on the product molecular weight 513.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.73 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for GDC 0941

References are publications that support the biological activity of the product.

Loh Protocol for efficient generation of human artery and vein endothelial cells from pluripotent stem cells. STAR Protoc. 2025 PMID: 39705146
Folkes The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J.Med.Chem. 2008 PMID: 18754654
Ang Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses. Cell 2022 PMID: 35738284