GC 1
Tocris Bioscience, part of Bio-Techne | Catalog # 4554
High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic
Key Product Details
Description
High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic
Alternative Names
Sobetirome
Product Description
GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.Product Specifications
Molecular Weight
328.40
Formula
C20H24O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
CAS Number
211110-63-3
PubChem ID
9862248
InChI Key
QNAZTOHXCZPOSA-UHFFFAOYSA-N
SMILES
CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(O)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.42 | 50 | |
| Ethanol | 16.42 | 50 |
Preparing Stock Solutions
for GC 1
The following data is based on the product molecular weight 328.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.09 mL | 30.45 mL | 60.90 mL |
| 2.5 mM | 1.22 mL | 6.09 mL | 12.18 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.09 mL |
| 25 mM | 0.12 mL | 0.61 mL | 1.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Johansson Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 2005 PMID: 16006512
- Columbano The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 2006 PMID: 16574785
- Chiellini A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 1998 PMID: 9653548
Product Specific Notices for GC 1
For research use only
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